Nanomaterials in live system


Nanomaterials as ecotoxicants and promising medical materials

Due to surface and quantum-dimensional effects, nanoscale materials have special structural, physicochemical, electrical and optical properties, which determines their effective use in most modern high-tech processes not only in the field of electronics, optoelectronics, laser technology, but also in biomedical, food and cosmetic technologies. Therefore, it is important to determine the mechanisms of action of nanomaterials in the event of their acute, short-term, subchronic intake into the body using the methods of physiology, biochemistry and cell biology. The research group of the Department of Molecular Biotechnology and Bioinformatics is carrying out a comprehensive study of the molecular and cellular mechanisms of functioning of visceral smooth muscles (in particular, stomach, large intestine and uterus) and liver under conditions of in vitro and in vivo exposure to nanomaterials (with different duration of intake). So far, the mechanisms of action of TiO2 and ZnO nanoparticles have been analysed in detail. It is planned to study the patterns of accumulation in tissues and the mechanisms of influence of noble metal nanoparticles on the state of the hepatobiliary system and the functioning of visceral smooth muscles.

Selected publications:

Tsymbalyuk, O. V., Davydovska, T. L., Naumenko, A. M., Voiteshenko, I. S., Veselsky, S. P., Nyporko, A. Y., Pidhaietska, A. Y., Kozolup, M. S., & Skryshevsky, V. A.  Mechanisms of regulation of motility of the gastrointestinal tract and the hepatobiliary system under the chronic action of nanocolloids. Scientific Reports 13, 3823 (2023).

Tsymbalyuk O. V., Hurskyi L. A., Davydovska T. L. et al. Mechanokinetics of the spontaneous contractions of smooth muscles in the stomach and large intestine of rats under chronic effect of TiO2 nanoparticles. Biol. Stud. 2023; 17(1): 19–34 DOI:

Tsymbalyuk O. V., Davydovska T. L., Naumenko A. M., Liashevych A. N., Lupaina I. S., Voiteshenko I. S., Nuryshchenko N. Y., Skryshevsky V. A. Functional state of the myometrium of rats under chronic in vivo effect of nanostructured ZnO and ТіО2 materials. Regulatory Mechanisms in Biosystems, 2021, 12(4): 581-587, DOI:;

Tsymbalyuk, O.Davydovska, T.Lisnyak, V., …Naumenko, A.Skryshevsky, V. ZnO and TiO2Nanocolloids: State of Mechanisms that Regulating the Motility of the Gastrointestinal Tract and the Hepatobiliary System ACS Omega, 2021, 6(37), P. 23960–23976

Tsymbalyuk O. V., Naumenko A.M., Rohovtsov O.O., Skoryk M.A., Voiteshenko I.S., Skryshevsky V.A., Davydovska T.L. Titanium Dioxide Modulation of the Contractibility of Visceral Smooth Muscles In Vivo. Nanoscale Research Letters. 2017; 12:129.

Contact: Prof. Olga Tsymbalyuk (,

Assoc. Prof. Ivan Voiteshenko (

Head of department Alex Nyporko (

Projects: The grant of the National Research Fund of Ukraine “Nanomaterials based on noble metals in biomedicine: a systematic study of biosafety issues” (2024-2025)

Nanomaterials in live system