Compounds with potential antitumor, antifibrotic and antiinflammatory activities


Biological effects and mechanisms of action of natural and artifical compounds with potential antitumor, antifbrotic and antinflammatory activities

Сurrent research

Discovering the impact of carbon-based nanoparticles on large intestine and liver inflammation, fibrosis, cirrhosis and neoplasia development using rodent in vivo models of liver diseases, the possible mechanisms of such impact, the stages of diseases’ progression most sensitive for therapeutic intervention; interconnection between liver diseases and other pathologies of the gut (especially IBD)

Acute colitis Cancer

Contact: Asis. Prof. Natalia Dzuibenko (,

Research Support

2019-2021 “Novel hybrid antitumor and anti-inflammatory nano-complexes based on pyrrole and C60-fullerene: development, characterization, pharmacodynamics and toxicological characteristics” –funded by Ministry of Education and Science of Ukraine.

2018-2020 “Biocompatible water-soluble C60 fullerenes as antifibrotic and antineoplastic treatment of liver malignancies” – funded by Ministry of Education and Science of Ukraine.

2016-2017 “Pyrrole derivatives as anti-inflammatory and anti-tumor compounds of new generation” – funded by Ministry of Education and Science of Ukraine.

2011-2015 “Mechanisms of adaptive-compensatory reactions under various pathologies” (subsection “Development of preventive and therapeutic methods, based on the investigation of digestive system function mechanisms under health and disease”) – funded by Ministry of Education and Science of Ukraine.

Selected Publications:

Kuznietsova, H., Dziubenko, N., Paliienko, K., Pozdnyakova, N., Krisanova, N., Pastukhov, A., Lysenko, T., Dudarenko, M., Skryshevsky, V., Lysenko, V., Borisova, T. A comparative multi-level toxicity assessment of carbon-based Gd-free dots and Gd-doped nanohybrids from coffee waste: hematology, biochemistry, histopathology and neurobiology study (2023) Scientific Reports, 13 (1), 9306, .

Howard, J.A., Kuznietsova, H., Dziubenko, N., Aigle, A., Natuzzi, M., Thomas, E., Lysenko, V., David, L., Brichart, T., Lux, F., Tillement, O. *

Combating lead and cadmium exposure with an orally administered chitosan-based chelating polymer (2023) Scientific Reports, 13 (1), 2215, .

Oliynyk, Z., Rudyk, M., Dovbynchuk, T., Dzubenko, N., Tolstanova, G., Skivka, L. Inflammatory hallmarks in 6-OHDA- and LPS-induced Parkinson’s disease in rats (2023) Brain, Behavior, and Immunity – Health, 30, 100616, .

Komarov, I.V., Tolstanova, G., Kuznietsova, H., Dziubenko, N., Yanchuk, P.I., Shtanova, L.Y., Veselsky, S.P., Garmanchuk, L.V., Khranovska, N., Gorbach, O., Dovbynchuk, T., Borysko, P., Babii, O., Schober, T., Ulrich, A.S., Afonin, S. Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and -dynamic data (2022) Journal of Photochemistry and Photobiology B: Biology, 233, 112479, .

Lynchak, O., Byelinska, I., Dziubenko, N., Kuznietsova, H., Abramchuk, O., Prylutska, S. Acute toxicity of C60–Cis-Pt nanocomplex in vivo (2022) Applied Nanoscience (Switzerland), 12 (3), pp. 439-447.

Stepanov, Y.V., Golovynska, I., Dziubenko, N.V., Kuznietsova, H.M., Petriv, N., Skrypkina, I., Golovynskyi, S., Stepanova, L.I., Stohnii, Y., Garmanchuk, L.V., Ostapchenko, L.I., Yevsa, T., Qu, J., Ohulchanskyy, T.Y. NMDA receptor expression during cell transformation process at early stages of liver cancer in rodent models *

(2022) American Journal of Physiology – Gastrointestinal and Liver Physiology, 322 (1), pp. G142-G153.

Compounds with potential antitumor, antifibrotic and antiinflammatory activities