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Комаров Ігор Володимирович igor.komarov@knu.ua Акаунт (профіль) в наукометричних базах даних: Scopus Wikipedia Georg Forster Research Award (2015) Merited Figure of Science and Technology of Ukraine (2016) |
Посада | директор інституту високих технологій |
Кафедра | Кафедра супрамолекулярної хімії |
Науковий ступінь (ступінь, спеціальність) | доктор хімічних наук |
Вчене звання | професор |
Публікації | |
Проекти | 1. “Peptidomimetics with Photocontrolled Biological Activity”, Horizon 2020 Research and Innovation Staff Exchange (RISE) Project (acronim PELICO), started in 2016. The Project Consortium: Enamine LLC (Ukraine), Chemistry Department of the University of Cambridge (United Kingdom), Latvian Institute of Organic Synthesis (Latvia), Karlsruhe Institute of Technology (Germany) (http://pelico.org/). The expertise, resources and specific knowledge of all Consortium Institutions is combined to achieve a breakthrough in design, synthesis and application of peptide analogues (peptidomimetics) possessing photo-controlled biological activities, with special emphasis on anti-microbial and anti-cancer activities. Role in the Project: coordinator (ongoing). 2. “Selective Agonists For Serotonin Receptors”, Horizon 2020 European Industrial Doctorates (EID) Project (acronim SAFER), started in 2017. The Project Consortium: Enamine LLC (Ukraine), Copenhagen University (Denmark), Saromics Biostructures AB (Sweden) (http://www.safer-itn.eu/research/). SAFER is the first European research platform to gain a molecular understanding and improve selectivity in stimulation of the serotonin 5-HT2A receptor – the primary target for many CNS-related disorders and hallucinogens. SAFER will design and prepare ligands for the receptor, generate and cross-interpret pharmacology and crystallographic data, and construct computational mechanistic models and databases. The SAFER network comprises five PhD students in pharmacology, chemistry, crystallography, computational drug design and scientific database development; first receiving 1-1,5 years joint training at the University of Copenhagen (Denmark) followed by industrial research at Enamine (Kiev, Ukraine) or SARomics (Lund, Sweden). Role in the Project: manager (ongoing). 3. „Photosensitive, fluorescent and fluorine-containing biologically active peptidomimetics for novel approaches in diagnostic and therapy”. An applied research financed by the Ukrainian State budget, state register number: 0116U004755, the work is carried out in Taras Shevchenko National University of Kyiv starting from 2016. Role in the Project: manager (ongoing). 4. ”Synthesis and study of small antimicrobial peptides containing conformationally constrained arginine analogues”, Alexander von Humboldt Foundation Research Group Linkage Program 3.4 - Fokoop - DEU/1136332, 01.07.2010 – 30.06.2013, the partner - Leibniz- Institut für Molekulare Pharmakologie Berlin (Germany). A collaboration with the German colleagues in the area of antimicrobial peptides as novel drug candidates. Role in the Project: coordinator (successfully completed). 5. “Accessing the structure of cell-penetrating peptides with rigid fluoro-substituted proline analogues as 19F-NMR labels”, Alexander von Humboldt Foundation Research Partnership Program 3 Fokoop DEU/1054096, 01.01.2006-31.12.2008, the partners - University of Karlsruhe (Germany) and Research Center Karlsruhe (Germany). This Collaboration Project was directed to studies of cell-penetrating peptides by NMR using fluorine-substituted amino acids as the labels. Role in the Project: coordinator (successfully completed). |
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